Ipamorelin — Selective Growth Hormone Releasing Peptide (GHRP)
Ipamorelin is a third-generation Growth Hormone Releasing Peptide (GHRP) designed for highly selective stimulation of the pituitary gland to release natural growth hormone (GH).
It mimics the effects of ghrelin without increasing appetite or causing unwanted side effects on cortisol or prolactin.
Because of its clean, targeted profile, Ipamorelin is a favored research peptide for studies on recovery, fat metabolism, anti-aging, and cellular repair.
Scientific Overview
Ipamorelin works by binding to the ghrelin receptor (GHS-R1a) in the anterior pituitary and hypothalamus, signaling a controlled release of endogenous GH.
Unlike earlier GHRPs such as GHRP-6 or Hexarelin, it produces a more physiologic GH pulse without spikes in ACTH, cortisol, or prolactin.
This makes it ideal for research focused on natural GH optimization and tissue regeneration.
- Increases natural GH and IGF-1 secretion
- Enhances fat metabolism and body composition
- Supports deeper sleep and faster recovery
- ⚙️ Promotes cellular repair and collagen synthesis
- Studied for anti-aging and neuroprotective properties
Product Specifications
| Compound | Ipamorelin |
| Sequence | Aib-HomoArg-Ala-Trp-D-Phe-Lys-NH₂ |
| CAS | 170851-70-4 |
| Molecular Weight | 711.9 g/mol |
| Form | Sterile lyophilized powder |
| Purity | ≥ 98% (HPLC) |
| Appearance | White/off-white crystalline |
⚗️ Mechanism of Action
Ipamorelin mimics the natural hunger-signaling peptide ghrelin to activate the GHS-R1a receptor.
This interaction promotes GH release in a dose-dependent, physiologic pulse that mirrors the body’s natural rhythm.
The resulting rise in GH and IGF-1 supports tissue regeneration, lipolysis, and protein synthesis — while minimizing side effects typical of earlier secretagogues.
Reconstitution & Storage
- Reconstitution: Reconstitute with Bacteriostatic Water (recommended 1–2 mL per vial).
Alternative options: Sterile Water (short-term ≤3 days) or 0.6% Acetic Acid (for long-term stability). - ❄️ Storage: Store lyophilized peptide in a cool, dark place (2–8 °C). After reconstitution, refrigerate and use within 20 days.
Research Applications
- Growth hormone release & IGF-1 modulation studies
- Fat metabolism & body-composition optimization models
- Sleep and recovery enhancement research
- Collagen synthesis & wound-healing mechanisms
- Neuroprotective and anti-aging investigations
Synergistic Pairings (Research Concepts)
- CJC-1295 — GHRH synergy for amplified GH pulses
- MK-677 — extended GH/IGF-1 elevation for recovery
- GHRP-2 / Hexarelin — comparative GH-release potency models
⚠️ Disclaimer
For Research Use Only. Not for human consumption, medical, or diagnostic use.
All information provided is for scientific and educational purposes.
Researchers must be 18 years or older.
All products are produced and handled under sterile laboratory conditions in compliance with research-grade standards.
