ACE-031 (Myostatin Inhibitor) — Research Peptide
ACE-031 is a recombinant fusion protein that functions as a powerful myostatin inhibitor. It was originally developed to treat muscle-wasting disorders such as muscular dystrophy by increasing lean muscle mass and improving strength through suppression of the myostatin signaling pathway. In research settings, ACE-031 has demonstrated the ability to enhance muscle growth, improve recovery, and increase physical performance potential.
Scientific Overview
ACE-031 acts as a soluble activin type IIB receptor (ActRIIB-Fc fusion protein) that binds and neutralizes myostatin and related ligands such as activins and GDF-11 — molecules known to restrict muscle growth. By inhibiting their activity, ACE-031 allows muscle fibers to grow larger and stronger.
- Increases lean muscle mass through myostatin inhibition
- ⚙️ Enhances muscle strength and density
- Improves recovery time and anabolic potential
- May reduce fat accumulation while promoting muscle hypertrophy
- Investigated for treating age-related muscle loss (sarcopenia) and cachexia
Product Specifications
| Compound: | ACE-031 |
| Synonyms: | Activin Receptor Type IIB-Fc fusion protein |
| CAS Number: | 946414-94-4 |
| Molecular Weight: | ~85 kDa (glycosylated protein) |
| Form: | Sterile lyophilized powder |
| Purity: | ≥ 98% (HPLC) |
⚗️ Mechanism of Action
Myostatin (GDF-8) is a natural inhibitor of skeletal muscle growth. It signals through activin type IIB receptors to suppress muscle cell differentiation and hypertrophy. ACE-031 works by mimicking these receptors and binding to myostatin, preventing it from attaching to native muscle receptors. This “decoy receptor” action effectively removes the brakes on muscle growth, allowing for enhanced anabolic signaling and muscle repair.
Reconstitution & Storage
- Reconstitution: Add Bacteriostatic Water (preferred) for longer stability.
Optional: Sterile Water for short-term use (less than 3 days). - ❄️ Storage: Store lyophilized powder in a cool, dry environment (2–8°C). Once reconstituted, refrigerate and use within 20 days.
Research Applications
- Muscle hypertrophy and strength enhancement models
- Myostatin and activin signaling pathway studies
- Research into sarcopenia and muscle-wasting conditions
- Evaluation of metabolic and fat-reducing effects
- ️ Performance and recovery optimization research
⚠️ Disclaimer
For Research Use Only. Not for human consumption, medical, or therapeutic use. All data and content provided are for educational and informational purposes only. This compound is intended exclusively for in vitro or laboratory-based research by qualified professionals. Users must be 18 years of age or older. Product handled in sterile facilities under research conditions.
