️ Thymosin Alpha-1 (Tα1) — Immune Modulating Peptide
Thymosin Alpha-1 (Tα1) is a 28–amino acid peptide best known for its role in t-cell maturation, dendritic cell activation, and innate/ adaptive immune balance.
In research settings, Tα1 has been investigated for support of host defense, immune resilience, and inflammatory tone, making it a valuable tool for immunology, recovery, and wellness studies.
Scientific Overview
Tα1 interfaces with Toll-like receptors (TLR2/4/9) and downstream NF-κB/IRF signaling to modulate cytokine profiles (e.g., ↑IL-2R expression, balanced Th1/Th2), enhance antigen presentation, and support cytotoxic lymphocyte activity.
Research highlights potential in immune optimization, vaccine adjuvancy models, and recovery from stressors.
- Promotes balanced immune signaling (innate ↔ adaptive)
- Enhances t-cell function & dendritic cell activity
- ️ Supports host defense & resilience research
- Helps regulate inflammatory tone
- Explored as an adjuvant in vaccine/response models
Product Specifications
| Compound | Thymosin Alpha-1 (Tα1) |
| Sequence | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (28 aa) |
| CAS | 62304-98-7 |
| Molecular Weight | ~3,108 Da |
| Form | Sterile lyophilized peptide powder |
| Purity | ≥ 98% (HPLC) |
| Appearance | White/off-white |
⚗️ Mechanism of Action
Through interaction with TLR pathways and upregulation of IL-2 receptor and co-stimulatory signals, Tα1 promotes:
- Improved antigen presentation (↑MHC expression on APCs)
- ⚔️ Enhanced t-cell differentiation & cytotoxic function
- Modulated cytokine milieu for balanced inflammation
- ️ Support for immune surveillance and recovery models
Reconstitution & Storage
- Reconstitution: Bacteriostatic Water recommended (1–2 mL per vial typical). Alternatives: Sterile Water (short-term ≤3 days) or 0.6% Acetic Acid for extended stability.
- ❄️ Storage: Keep lyophilized vials refrigerated (2–8 °C), protected from light. After reconstitution, refrigerate and use within 20 days.
Research Applications
- ️ Immune modulation & host-defense studies
- Vaccine adjuvant/response and antigen-presentation models
- Inflammatory balance & recovery from physiological stress
- Combination immunopeptide research (e.g., with TB-500/BPC-157/LL-37)
Stack Synergy (Research Concepts)
- TB-500 (Thymosin Beta-4) — tissue repair & cytoskeletal support
- BPC-157 — GI/muscle recovery models & angiogenesis support
- LL-37 — innate defense & antimicrobial research
⚠️ Disclaimer
For Research Use Only. Not for human consumption, diagnostic, or therapeutic purposes.
All information is provided for educational and laboratory research by qualified professionals.
Researchers must be 18+ years old. Materials are produced and handled in sterile research facilities.
By purchasing or accessing this item, you confirm compliance with all applicable research laws and guidelines.
