Follistatin-344 (Myostatin Binding Protein) — Research Peptide
Follistatin-344 is a naturally occurring glycoprotein peptide known for its potent ability to inhibit myostatin — the key regulator that limits muscle growth. By binding and neutralizing myostatin and activin molecules, Follistatin effectively removes the natural “brakes” on muscle development, making it one of the most powerful anabolic signaling peptides studied in modern biotechnology.
Scientific Overview
Follistatin-344 is a bioactive fragment of the full-length Follistatin protein produced in various tissues, including skeletal muscle. Its core function is to bind to and inhibit transforming growth factor-beta (TGF-β) family proteins such as myostatin (GDF-8) and activin A. By doing so, it promotes muscle cell differentiation, hypertrophy, and repair.
- Promotes rapid lean muscle growth
- ⚙️ Suppresses myostatin & activin signaling
- Supports muscle recovery & tissue regeneration
- Enhances strength, endurance, and performance potential
- Investigated for anti-aging and metabolic health benefits
Product Specifications
| Compound: | Follistatin-344 |
| Sequence: | MSTN-binding protein fragment (amino acids 44-344) |
| CAS Number: | 80449-31-6 |
| Molecular Formula: | C1565H2464N438O452S10 |
| Form: | Lyophilized powder |
| Purity: | ≥ 98% (HPLC) |
⚗️ Mechanism of Action
Follistatin binds directly to myostatin and activin A, forming inactive complexes that prevent them from binding to their receptors on muscle cells. This results in:
- Increased muscle fiber size and density (hypertrophy)
- Enhanced satellite cell activation for muscle regeneration
- Improved anabolic environment within skeletal muscle tissue
- Potential protective effect on neuromuscular degeneration
Reconstitution & Storage
- Reconstitution: Reconstitute with Bacteriostatic Water (recommended) for long-term stability.
Alternative: Sterile Water for short-term use or 0.6% Acetic Acid for extended preservation. - ❄️ Storage: Store lyophilized powder in a cool, dark place. Once reconstituted, keep refrigerated (2–8°C) and use within 20 days.
Research Applications
- ️ Skeletal muscle growth and regeneration studies
- Myostatin inhibition & hypertrophy research
- Post-injury or degenerative muscle recovery models
- Anti-aging and metabolic enhancement research
- ⚙️ Performance optimization and cellular repair mechanisms
⚠️ Disclaimer
For Research Use Only. This compound is not intended for human consumption, therapeutic, or diagnostic use. All information is provided for educational and research purposes. Researchers must be 18 years of age or older. Product handled under sterile conditions in certified facilities. Use of this material signifies agreement to compliance with all applicable research regulations.
